Every Wednesday, the Upright Citizens Brigade hosts an improv show that uses actual Facebook pages of audience members as its jumping-off point.
From the UCB website:
Each week two audience members are randomly plucked from the audience to get their Facebook page examined and then turned into long-form improvised comedy scenes based entirely on their profile, pictures, comments and status.
Check their website for more details. Also, try and plan ahead on this, as shows have a tendency to sell out quickly.